ACUTE DRUG OVERDOSE IN PATIENTS WITH HIV INFECTION: PREDICTORS OF POOR OUTCOME

Resumen

Background. Illicit drugs are widely used by the HIV population according to recent studies. Based on this, we analyze the role of them in acute overdose.

Methods. Retrospective, single-center study. Patients included in this study were all HIV infected patients that went to our center for acute street drug overdose during the period 2018-2019. Clinical characteristics of the population, prevalence of illicit drugs acute intoxication and predictors of poor outcome during the study were assessed. All statistical analyses were calculated by SPSS version 20.0 (Chicago, IL, USA).

Results. In the time period reviewed, 163 patients were identified. The mean age was 37.2 (31-43) years old, 153 patients were male (94%). Sixty patients (37%) had previous psychiatric disorders. One hundred forty-two patients (81%) were on ART. The most frequent ART regimen was integrase inhibitors in 67% of the patients. Among 20% (n=32) of the study population received cobicistat-boosted therapy. The main drug involved was amphetamine in 82 patients (50%), followed by gamma-hydroxybutyrate in 76 patients (47%). Drug polycomsuption (at least 2 drugs) was observed in 72 patients (44%). Factors associated with hospital admission in the univariate analysis were benzodiazepine consumption (p=0.002), non-boosted ART regimen (p=0.045) and drug use not related to Chemsex (p=0.001). In the multivariate analysis, benzodiazepine consumption was associated with hospital admission [p=0.001, QR 377 (IC 95; 1-13)]. The 30-day mortality was 2%.

Conclusion. We reviewed the impact of these situations in our area, confirming a complex management (polyconsumption and ART) and high need for psychiatric assessment (previous diseases).